Medicine

How Did the World Miss Covid-19's Silent Spread? (nytimes.com) 265

Long-time Slashdot reader hankwang writes: The New York Times has an article on how the transmission of Covid-19 by seemingly healthy individuals was discovered in Germany on January 27, but the report was discredited because of a quibble over whether it was really asymptomatic or rather presymptomatic or oligosymptomatic transmission. Oligosymptomatic means that the symptoms are so mild that they are not recognized as symptoms... It took until March before asymptomatic transmission was publicly acknowledged as playing a significant role.
From the article. (Alternate source here): Dr. Rothe, an infectious disease specialist at Munich University Hospital, and her colleagues were among the first to warn the world [on January 30]. But even as evidence accumulated from other scientists, leading health officials expressed unwavering confidence that symptomless spreading was not important. In the days and weeks to come, politicians, public health officials and rival academics disparaged or ignored the Munich team. Some actively worked to undermine the warnings at a crucial moment, as the disease was spreading unnoticed...

It is now widely accepted that seemingly healthy people can spread the virus, though uncertainty remains over how much they have contributed to the pandemic. Though estimates vary, models using data from Hong Kong, Singapore and China suggest that 30 to 60 percent of spreading occurs when people have no symptoms... The Chinese health authorities had explicitly cautioned that patients were contagious before showing symptoms. A Japanese bus driver was infected while transporting seemingly healthy tourists from Wuhan. And by the middle of February, 355 people aboard the Diamond Princess cruise ship had tested positive. About a third of the infected passengers and staff had no symptoms...

[P]ublic health officials saw danger in promoting the risk of silent spreaders. If quarantining sick people and tracing their contacts could not reliably contain the disease, governments might abandon those efforts altogether... Plus, preventing silent spreading required aggressive, widespread testing that was then impossible for most countries. "It's not like we had some easy alternative," said Dr. Libman, the Canadian doctor. "The message was basically: 'If this is true, we're in trouble.'" European health officials say they were reluctant to acknowledge silent spreading because the evidence was trickling in and the consequences of a false alarm would have been severe...

As the research coalesced in March, European health officials were convinced. "OK, this is really a big issue," Dr. Agoritsa Baka, a senior European Union doctor, recalled thinking. "It plays a big role in the transmission..." Since then, the C.D.C., governments around the world and, finally, the World Health Organization have recommended that people wear masks in public.

EU

Sweden Tries Out a New Status: Pariah State (sfgate.com) 382

Sweden's population is not quite twice the size of Norway's — yet Sweden has reported 21 times as many deaths from Covid-19, prompting many countries to close their borders to Sweden, reports the New York Times: Norway isn't the only Scandinavian neighbor barring Swedes from visiting this summer. Denmark and Finland have also closed their borders to Swedes, fearing that they would bring new coronavirus infections with them. While those countries went into strict lockdowns this spring, Sweden famously refused, and now has suffered roughly twice as many infections and five times as many deaths as the other three nations combined, according to figures compiled by The New York Times. While reporting differences can make comparisons inexact, the overall trend is clear, as is Sweden's new status as Scandinavia's pariah state...

"When you see 5,000 deaths in Sweden and 230 in Norway, it is quite incredible," said Gro Harlem Brundtland, a former prime minister of Norway and the former director of the World Health Organization, during a digital lecture at the Norwegian Academy of Science and Letters in May...

Swedes now find themselves with few options for moving about the European Union. Most countries in the bloc have reopened their borders to member nations, but only France, Italy, Spain and Croatia are welcoming Swedes without restrictions.

On a popular Scandinavian radio program, a journalist with a leading Swedish paper complained about how Sweden was being treated by its neighboring countries, according to the Times. "We are supposed to sit here in our corner of shame, and the worst part is that you're savoring it."

The BBC notes that just days later, on Wednesday, Sweden reported 1,610 new infections — roughly one infection for every 6,354 people in Sweden and its highest number of daily infections since the outbreak began.
Science

CRISPR Gene Editing In Human Embryos Wreaks Chromosomal Mayhem (nature.com) 87

A suite of experiments that use the gene-editing tool CRISPR-Cas9 to modify human embryos have revealed how the process can make large, unwanted changes to the genome at or near the target site. Nature reports: The first preprint was posted online on June 5 by developmental biologist Kathy Niakan of the Francis Crick Institute in London and her colleagues. In that study, the researchers used CRISPR-Cas9 to create mutations in the POU5F1 gene, which is important for embryonic development. Of 18 genome-edited embryos, about 22% contained unwanted changes affecting large swathes of the DNA surrounding POU5F1. They included DNA rearrangements and large deletions of several thousand DNA letters -- much greater than typically intended by researchers using this approach. Another group, led by stem-cell biologist Dieter Egli of Columbia University in New York City, studied embryos created with sperm carrying a blindness-causing mutation in a gene called EYS2. The team used CRISPR-Cas9 to try to correct that mutation, but about half of the embryos tested lost large segments of the chromosome -- and sometimes the entire chromosome -- on which EYS is situated. And a third group, led by reproductive biologist Shoukhrat Mitalipov of Oregon Health & Science University in Portland, studied embryos made using sperm with a mutation that causes a heart condition. This team also found signs that editing affected large regions of the chromosome containing the mutated gene.

The three studies offered different explanations for how the DNA changes arose. Egli and Niakan's teams attributed the bulk of the changes observed in their embryos to large deletions and rearrangements. Mitalipov's group instead said that up to 40% of the changes it found were caused by a phenomenon called gene conversion, in which DNA-repair processes copy a sequence from one chromosome in a pair to heal the other. Mitalipov and his colleagues reported similar findings in 2017, but some researchers were skeptical that frequent gene conversions could occur in embryos. They noted that the maternal and paternal chromosomes are not next to each other at the time the gene conversion is postulated to occur, and that the assays the team used to identify gene conversions could have been picking up other chromosomal changes, including deletions. Egli and his colleagues directly tested for gene conversions in their latest preprint and failed to find them, and Burgio points out that the assays used in the Mitalipov preprint are similar to those the team used in 2017. One possibility is that DNA breaks are healed differently at various positions along the chromosome, says Jin-Soo Kim, a geneticist at Seoul National University and a co-author of the Mitalipov preprint.

Medicine

CA Governor Newsom Announces COVID-19 Modeling Website, Open-Source Tools For 'Citizen Scientists' (cbslocal.com) 89

Long-time Slashdot reader PCM2 shares a report from CBS News: Gov. Gavin Newsom on Thursday announced a new COVID-19 modeling website as well as new open-source tools designed to help California residents understand the data informing local health departments and empower what he called "citizen scientists." The governor introduced the new coronavirus modeling website [...] as a way for residents to see the raw data that is driving the decisions of state and county officials with full transparency.

The new website features three sections: a "Nowcast" section that provides the most current information on how fast COVID-19 is spreading in the state and by county; a "Forecasts" section that provides short-term COVID-19 forecasts in the state and by county; and a "Scenarios" section that projects the possible long-term impacts under different scenarios and responses to COVID-19, again for the whole state and by county.
"We want to open up our site to 'netizen-tists' ... of citizen-scientists, people that are out there doing coding every single day," said Newsom. "We want to give them access through an open-source platform to all of the available data that we have, that I have, that our health professionals have, in a way that we don't believe has been done before anywhere in the United States. This is a deep dive for transparency and openness. This is a new resource that we are making available today."
ISS

One Lucky Space Tourist Could Get a Shot At An ISS Spacewalk In 2023 (cnet.com) 37

Space tourism company Space Adventures announced a deal on Thursday with the S.P. Korolev Rocket and Space Corporation to fly two space tourists to the International Space Station. What makes this contract an eye-opener is that it would give one of the tourists an opportunity to go for a spacewalk outside the ISS. CNET reports: Space Adventures said this person would become "the first private citizen in history to experience open space." The S.P. Korolev Rocket and Space Corporation (known as Energia) makes the Soyuz equipment for Russia's space agency Roscosmos, which confirmed the Space Adventures agreement on Thursday. Roscosmos is targeting the flight for 2023.

The spacewalking tourist won't be sent out of the air hatch alone. A professional cosmonaut will go along. The spacewalk will also call for quite a bit of prep work. "Accepted and secured candidates will be required to complete specialized training and additional simulations in preparation for the spacewalk attempt," Space Adventures said. The flight will take place using a Russian Soyuz spacecraft, and the spacewalk participant will stay at the Russian segment of the station for 14 days.

Medicine

CDC: Coronavirus May Have Infected 10 Times More Americans Than Known 510

Nearly 25 million Americans may have contracted the coronavirus, a figure 10 times higher than the number of confirmed cases, the Centers for Disease Control and Prevention (CDC) said Thursday. The Hill reports: In a briefing with reporters Thursday, CDC Director Robert Redfield said surveys of blood samples taken from around the country suggest that millions of Americans may have contracted the virus either without knowing it or with only minimal symptoms. For every one confirmed case, Redfield said, the CDC estimates that 10 more people have been infected. "This virus causes so much asymptomatic infection," Redfield said. "We probably recognized about 10 percent of the outbreak."

Almost 2.4 million Americans have tested positive for the coronavirus, according to the Center for Systems Science and Engineering at the Johns Hopkins University of Medicine. Redfield said the serological surveys of blood samples, collected both for coronavirus tests and for other reasons like blood donations or laboratory tests, showed that between 5 percent and 8 percent of Americans have contracted the virus. Most people who contract the SARS-CoV-2 virus show few if any symptoms, and only a small percentage require hospitalization. But while the number of potentially infected people is multitudes higher than the number of confirmed cases, Redfield also said the relatively low percentage of Americans who have been infected means hundreds of millions more remain at risk.
Earth

Arctic Records Its Hottest Temperature Ever (cbsnews.com) 100

An anonymous reader quotes a report from CBS News: Alarming heat scorched Siberia on Saturday as the small town of Verkhoyansk (67.5N latitude) reached 100.4 degrees Fahrenheit, 32 degrees above the normal high temperature. If verified, this is likely the hottest temperature ever recorded in Siberia and also the hottest temperature ever recorded north of the Arctic Circle, which begins at 66.5 degrees North. The town is 3,000 miles east of Moscow and further north than even Fairbanks, Alaska. On Friday, the city of Caribou, Maine, tied an all-time record at 96 degrees Fahrenheit and was once again well into the 90s on Saturday. To put this into perspective, the city of Miami, Florida, has only reached 100 degrees one time since the city began keeping temperature records in 1896.

Verkhoyansk is typically one of the coldest spots on Earth. This past November, the area reached nearly 60 degrees Fahrenheit below zero, one of the first spots to drop that low in the winter of 2019-2020. Reaching 100 degrees in or near the Arctic is almost unheard of. Although the reading is questionable, back in 1915 the town of Fort Yukon, Alaska, not quite as far north as Verkhoyansk, is reported to have reached near 100 degrees. And in 2010 a town a few miles south of the Arctic circle in Russia reached 100. As a result of the hot-dry conditions right now, numerous fires rage nearby, and smoke is visible for thousands of miles on satellite images.

Space

Gravitational Waves Reveal Lightest Black Hole Ever Observed (sciencemag.org) 44

sciencehabit shares a report from Science Magazine: Gravitational wave detectors have spotted a cosmic collision in which a giant black hole swallowed up a mystery object seemingly too heavy to be a neutron star, but too light to be a black hole. Weighing in at 2.6 times the mass of the Sun, the object falls into a hypothetical "mass gap," a desert between the heaviest neutron star and the lightest black hole that some theories predict -- suggesting the gap doesn't exist and that those theories need to be amended. The data come from physicists working with the Laser Interferometer Gravitational-Wave Observatory (LIGO), a pair of detectors in Louisiana and Washington state, and Virgo, a similar detector in Italy.

It's the 2.6-solar-mass object that raises eyebrows because it falls squarely in the mass gap, says Vicky Kalogera, an astrophysicist and LIGO team member from Northwestern University. "Now, for the first time, we have seen such an object," she says. By sensing only the gravitational waves from the collision, LIGO and Virgo cannot tell for sure what the object is, she says. But nuclear physics suggests a neutron star heavier than about 2.2 solar masses cannot support its own weight, so the object is "almost certainly" a black hole, Miller says.
The study has been published in The Astrophysical Journal Letters.
Facebook

Facebook Creates Fact-Checking Exemption for Climate Deniers (popular.info) 257

Facebook is "aiding and abetting the spread of climate misinformation," said Robert Brulle, an environmental sociologist at Drexel University. "They have become the vehicle for climate misinformation, and thus should be held partially responsible for a lack of action on climate change." From a report: Brulle was reacting to Facebook's recent decision, made at the request of climate science deniers, to create a giant loophole in its fact-checking program. Last year, Facebook partnered with an organization, Science Feedback, that would bring in teams of Ph.D. climate scientists to evaluate the accuracy of viral content. It was an important expansion of the company's third-party fact-checking program. But now Facebook has reportedly decided to allow its staffers to overrule the climate scientists and make any climate disinformation ineligible for fact-checking by deeming it "opinion."

The organization that requested the change, the CO2 Coalition, is celebrating, E&E news reported on Monday. The group, which has close ties to the fossil fuel industry, says its views on climate change are increasingly ignored by the mainstream media. Now it plans to use Facebook to aggressively push climate misinformation on the public -- without having to worry about fact checks from climate scientists. A column published in the Washington Examiner in August 2019 claimed that "climate models" were a "failure" that predicted exponentially more warming of the earth than has occurred. The piece, co-authored by notorious climate science denier Pat Michaels, was quickly shared more than 2,000 times on Facebook. There was just one issue: It wasn't true. This is exactly the kind of mess that Facebook's network of independent fact-checkers is supposed to solve.

Mars

Mars Is About To Have Its 'Wright Brothers Moment' (nytimes.com) 80

As part of NASA's next mission to Mars, leaving Earth this summer, the space agency will attempt to do something that has never been done before: fly a helicopter through the rarefied atmosphere of Mars. The New York Times reports: If it works, the small helicopter, named Ingenuity, will open a new way for future robotic explorers to get a bird's-eye view of Mars and other worlds in the solar system. "This is very analogous to the Wright brothers moment, but on another planet," said MiMi Aung, the project manager of the Mars helicopter at NASA's Jet Propulsion Laboratory over the past six years.

Flying on Mars is not a trivial endeavor. There is not much air there to push against to generate lift. At the surface of Mars, the atmosphere is just 1/100th as dense as Earth's. The lesser gravity -- one-third of what you feel here -- helps with getting airborne. But taking off from the surface of Mars is the equivalent of flying at an altitude of 100,000 feet on Earth. No terrestrial helicopter has ever flown that high, and that's more than twice the altitude that jetliners typically fly at. The copter will hitch a ride to the red planet with Perseverance, which is to be the fifth robotic rover NASA has sent there. The mission is scheduled to launch on July 20, one of three missions headed to Mars this year. At a news conference last week previewing the Perseverance mission, Jim Bridenstine, the NASA administrator, made a point to highlight Ingenuity. "I'll tell you, the thing that has me the most excited as an NASA administrator is getting ready to watch a helicopter fly on another world," he said.

AI

Teaching Physics To Neural Networks Removes 'Chaos Blindness' (phys.org) 58

An anonymous reader quotes a report from Phys.Org: Researchers from North Carolina State University have discovered that teaching physics to neural networks enables those networks to better adapt to chaos within their environment. Neural networks are an advanced type of AI loosely based on the way that our brains work. Our natural neurons exchange electrical impulses according to the strengths of their connections. Artificial neural networks mimic this behavior by adjusting numerical weights and biases during training sessions to minimize the difference between their actual and desired outputs. For example, a neural network can be trained to identify photos of dogs by sifting through a large number of photos, making a guess about whether the photo is of a dog, seeing how far off it is and then adjusting its weights and biases until they are closer to reality.

The drawback to this neural network training is something called "chaos blindness" -- an inability to predict or respond to chaos in a system. Conventional AI is chaos blind. But researchers from NC State's Nonlinear Artificial Intelligence Laboratory (NAIL) have found that incorporating a Hamiltonian function into neural networks better enables them to "see" chaos within a system and adapt accordingly. Simply put, the Hamiltonian embodies the complete information about a dynamic physical system -- the total amount of all the energies present, kinetic and potential. Picture a swinging pendulum, moving back and forth in space over time. Now look at a snapshot of that pendulum. The snapshot cannot tell you where that pendulum is in its arc or where it is going next. Conventional neural networks operate from a snapshot of the pendulum. Neural networks familiar with the Hamiltonian flow understand the entirety of the pendulum's movement -- where it is, where it will or could be, and the energies involved in its movement.

In a proof-of-concept project, the NAIL team incorporated Hamiltonian structure into neural networks, then applied them to a known model of stellar and molecular dynamics called the Henon-Heiles model. The Hamiltonian neural network accurately predicted the dynamics of the system, even as it moved between order and chaos. "The Hamiltonian is really the 'special sauce' that gives neural networks the ability to learn order and chaos," says John Lindner, visiting researcher at NAIL, professor of physics at The College of Wooster and corresponding author of a paper describing the work. "With the Hamiltonian, the neural network understands underlying dynamics in a way that a conventional network cannot. This is a first step toward physics-savvy neural networks that could help us solve hard problems."
The work appears in the journal Physical Review E.
Medicine

Fauci 'Cautiously Optimistic' Vaccine Could Be Available by End of 2020 or Early 2021 (bostonglobe.com) 165

Dr. Anthony Fauci, the government's top infectious disease expert, told a House committee on Tuesday he believes "it will be when and not if" there will be a COVID-19 vaccine and that he remains "cautiously optimistic" that some will be ready at the end of the year. From a report: Fauci has returned to Capitol Hill at a fraught moment in the nation's pandemic response, with coronavirus cases rising in about half the states and political polarization competing for attention with public health recommendations. Fauci testified in his opening statement that a vaccine candidate for the coronavirus will enter Phase 3 of study in July. "This is one that has already shown in preliminary studies some very favorable response in the animal models that we've developed," Fauci said. Earlier this month, Cambridge-based Moderna announced the experimental COVID-19 vaccine it is developing with the US National Institutes of Health was on track to be tested in 30,000 volunteers -- some given the real shot and some a dummy shot.

Fauci was testifying along with the heads of the Centers for Disease Control and Prevention, the Food and Drug Administration, and a top official at the Department of Health and Human Services. Since Fauci's last appearance at a high-profile hearing more than a month ago, the US has been emerging from weeks of stay-at-home orders and business shutdowns. But it's being done in an uneven way, with some states far less cautious than others. A trio of states with Republican governors who are bullish on reopening -- Arizona, Florida and Texas -- are among those seeing worrisome increases in cases. Last week, Vice President Mike Pence published an opinion article in The Wall Street Journal saying the administration's efforts have strengthened the nation's ability to counter the virus and should be "a cause for celebration."
Dr. Fauci also told lawmakers Tuesday that the US will be increasing coronavirus testing, saying, "we're going to be doing more testing, not less," in response to President Donald Trump's recent claim that he asked to slow down testing during the pandemic.
Bug

Stuck At Home, Scientists Discover 9 New Insect Species (wired.com) 35

An anonymous reader quotes a report from Wired: When the Natural History Museum of Los Angeles County shut down due to the pandemic in mid-March, Lisa Gonzalez headed home with the expectation that she would be back in a few weeks. But once it became clear that she wouldn't get back anytime soon, Gonzalez, the museum's assistant entomology collection manager, converted her home's craft room into a makeshift lab. Then she began sifting through thousands of insects the museum had previously collected via a citizen science project. [...] Using just her own microscope, Gonzalez identified dozens of insect species by looking at features like tiny hairs or the shape of a fly's wings. She also found some unusual insects that she turned over to her colleague, Brian Brown, the museum's curator of entomology. Using a larger Leica stereoscope that he hauled in from the office, as well as a smaller compound microscope he found on craigslist, Brown discovered nine species of small flies, all new to science. "It's always cool to find new things, and it is one of the great joys of this job," says Brown. "It's not just finding slightly different new things -- we find extravagantly different things all the time."

The insects, mostly small flies, wasps, and wasplike flies, had been collected through the BioSCAN project, which began in 2012 with insect traps set at 30 sites throughout Los Angeles, mostly in backyards or public spaces. The pair recruited volunteers who were then trained in how to use the "Malaise traps," which resemble two-person pup tents that force bugs to fly upward into collecting nets before the volunteers can put them into vials. The BioSCAN project started when Brown bet a museum trustee that he could find a new species of insect in her backyard in West LA. He did, and the project took off. In its first three years, Brown and the backyard collector discovered 30 new species of insects and published their results. The museum team found an additional 13 new species in the past two years, plus he and the staff have discovered nine more since the pandemic shutdown.
"The nine new species include phorid flies, some of which are known for their ability to run across surfaces and or enter coffins to consume dead bodies," the report adds. "Brown and Gonzalez have also found botflies, parasites of rats and wasplike flies that have never been seen before in Southern California. They likely arrived from Central America, perhaps hitching a ride on a flowering plant or piece of food."

"With the help of tens of thousands of insects collected through the BioSCAN project, over the years Brown and Gonzalez have expanded the count of known insect species in the Los Angeles basin from 3,500 during the last census in 1993 to around 20,000 today."
Government

How Did Vietnam Become the Largest Nation Without Coronavirus Deaths? (voanews.com) 179

Vietnam has reported no coronavirus deaths — and, for more than two months, no local infections (with a total for this year of just 349) — despite having a population of 97 million and a border shared with China. VOA News takes a closer look: It is hard for outsiders to verify official data, though health experts say Vietnam headed off a full-blown calamity because of its drastic and early action. The government was hyper-aware of the threat to hospital and quarantine capacity... Vietnam saw the disease as a threat early on, treating its first patient in January and proceeding to contact trace and restrict movement. Timing was critical because of the virus' ability to spread exponentially. The Ho Chi Minh City government said, for instance, that for every 300 people infected, 84,000 people had to quarantine. It is likely that Vietnam did not have to cover up mass infections and deaths because it acted before the virus could reach that point...

In addition to national coordination, targeted testing and isolation, Vietnam can decree measures regardless of public debate, like tapping a national security network to monitor the physical and virtual space... On one hand, Vietnam used fines and takedown orders to curb the spread of false information about the virus, as have other nations. On the other hand, the controls continue a history of censorship of information that the Southeast Asian government considers unfavorable.

Social media allowed some false information to spread in Vietnam, but also greatly heightened people's awareness of the virus and what they should do, concluded a study by 11 authors published in April in Sustainability, a science journal. Vietnam's success, they said, came from "mobilizing citizens' awareness of disease prevention without spreading panic, via fostering genuine cooperation between government, civil society and private individuals."

Some examples from the article:
  • Standing vice chairman of the People's Committee, Le Thanh Liem, urged local authorities and other relevant agencies to visit every house to find out if anyone had come from other countries since March 8 and test and quarantine anyone at risk at home or quarantine areas.
  • Those entering a cafe have a good chance of meeting a security guard who sprays their hands with disinfectant.
  • If getting on a bus, they will be told to put on a mask and sit one row apart from others.

NASA

Washington Post: A Top NASA Official Improperly Contacted Boeing (washingtonpost.com) 34

The Washington Post reports: After a top NASA official improperly contacted a senior Boeing executive about a bid to win a contract potentially worth hundreds of millions of dollars, the company attempted to amend its proposal past the deadline for doing so, according to people with knowledge of the matter. That raised alarm bells inside the space agency, where officials were concerned that Boeing was attempting to take advantage of inside information. Ultimately, the matter was referred to NASA's inspector general office, and NASA's leadership last month forced Doug Loverro to resign from his position as the associate administrator of NASA's human spaceflight directorate.

Boeing did not win one of the lucrative contracts to build a system capable of landing astronauts on the moon. But the inspector general investigation could be another headache for a company under fire for having an unusually cozy relationship with federal regulators, especially if it identifies wrongdoing on the part of Boeing senior executives... "It's one thing to have a mistake that violated the Integrity in Procurement Act," according to a congressional aide with knowledge of the matter. "It's another if the company took that information and acted on it."

Space

Space Startup Promises 30-Mile-High Balloon Rides to the 'Edge of Space' (cbsnews.com) 61

An anonymous reader quotes CBS News: Researchers, armchair astronauts and even brides and grooms looking for an out-of-this-world wedding experience will be able to celebrate, collect data or simply enjoy the view from an altitude of 100,000 feet in a balloon-borne pressurized cabin, complete with a bar and a restroom, a space startup announced Thursday.

"Spaceship Neptune," operated by a company called Space Perspective from leased facilities at NASA's Kennedy Space Center, will carry eight passengers at a time on six-hour flights [with a crew member]. The passenger cabin, lifted by a huge hydrogen-filled balloon, will climb at a sedate 12 miles per hour to an altitude of about 30 miles high. That will be followed by a slow descent to splashdown in the Atlantic Ocean where a recovery ship will be standing by to secure the cabin and crew.

Test flights carrying scientific research payloads are expected to begin in 2021. The first flights carrying passengers are expected within the next three-and-a-half years or so, with piloted test flights before that. While the company initially will operate out of the Florida spaceport, the system could be launched from multiple sites around the world, with Hawaii and Alaska near-term possibilities.

They're expecting to charge around $125,000 per passenger, according to the article — about half the price of higher sub-orbital flight on a Virgin Galactic rocket-powered spaceplane. Though Spaceship Neptune's customers will not experience weightlessness, their CEO is still promising "opportunities for civilian astronauts to experience this planet Earth from the edge of space, a privilege previously available to only a few."

And they're also touting "really great" live air-to-ground communication — which they think would be great for corporate events.
Medicine

Quest for a Vaccine: Oxford Reaches Final Large-Scale Trial (msn.com) 256

An anonymous reader quotes The Washington Post: In the global race for a coronavirus vaccine, more than 100 labs, universities and drug companies have started off on experimental missions. But just 11 candidate vaccines, according to the World Health Organization, have reached the stage of clinical testing. The WHO says that only Oxford University's vaccine has reached what is known as Phase 3, the final and largest-scale trial... "There is quite a strong probability that the vaccine will work," said Walter Ricciardi, the World Health Organization's Italian government adviser.

But the vaccine is far from a sure thing, according to experts. It might not work, or it might give immunity to only some of those who are injected. Even once a vaccine makes it to market, it remains unknown whether it will offer long-term protection, or only for a year or two. The world will ultimately need more than one vaccine anyway, as demand will soar beyond what any one company could produce. "The expectation is that we will have a protective vaccine. Probably more than one," said Antonio Cassone, the former head of the infectious-disease department at Italy's national health institute.

"But nobody will know at that time how long the protection will last. We don't know the antibody duration. This will be yet another jump into the unknown."

A Chinese biotech firm has reported encouraging results in early-stage clinical trials and is also among the front-runners to crack the vaccine code.

The article adds that Oxford's vaccine "proved effective and safe with rhesus monkeys during the earliest stage of experimentation."
Earth

America Can Achieve Its 90% Clean Energy Goals 15 Years Early (berkeley.edu) 241

destinyland writes: Most studies aim for deep decarbonization of electric power systems by 2050," argues a new study from the Center for Environmental Public Policy at the University of California, Berkeley. But they've produced a new report — "the first to show we can get there in half that time with the latest renewable energy and battery cost data."

"Plummeting costs for wind and solar energy have dramatically changed the prospects for rapid, cost-effective expansion of renewable energy," announces UC Berkeley's School of Public Policy.

Even with no policy changes, they predict that by 2035 America will have achieved 55% clean energy usage (due to increases in solar and wind power) while experiencing a 10% reduction in electricity costs. But under their 90% Clean (carbon-free) scenario, "all existing coal plants are retired by 2035, and no new fossil fuel plants are built," meaning the country "avoids over $1.2 trillion in health and environmental costs, including 85,000 avoided premature deaths, through 2050."

During normal periods of generation and demand, wind, solar, and batteries provide 70% of annual generation, while hydropower and nuclear provide 20%. During periods of very high demand and/or very low renewable generation, existing natural gas, hydropower, and nuclear plants combined with battery storage cost-effectively compensate for mismatches between demand and wind/solar generation. Generation from natural gas plants constitutes about 10% of total annual electricity generation, which is about 70% lower than their generation in 2019.

"Without robust policy reforms," their announcement adds, "most of the potential to reduce emissions and increase jobs would not be realized."

Mars

Help a Mars Rover's AI Learn to Tell Rocks From Dirt (techcrunch.com) 18

Slashdot reader shirappu writes: For eight years now, the Mars Rover Curiosity has been exploring the surface of Mars. Even now, it's still exploring, and still getting upgrades. According to Tech Crunch, NASA is now looking to interested volunteers to help upgrade the rover's terrain-scanning AI systems by annotating image data of the planet itself.
"The problem is that while there are lots of ready-made data sets of images with faces, cats and cars labeled, there aren't many of the Martian surface annotated with different terrain types..." notes TechCrunch. "Improvements to the AI might let the rover tell not just where it can drive, but the likelihood of losing traction and other factors that could influence individual wheel placement."

shirappu continues: Volunteers go through a short tutorial after which they can label images to help the rover better understand the terrain on which it drives. The system is expected to be used in future planet rover robots, and the project marks an interesting example of open crowd-sourcing to improve machine learning systems, and how it is impacting technology even on other planets.

Click this link for the AI4Mars site link where people can volunteer.

United States

The US Government Is Now Stuck with 63 Million Doses of Hydroxychloroquine (cnn.com) 310

The World Health Organization has now halted research on whether hydroxychloroquine could be an effective treatment for COVID-19, reports NBC News, after multiple studies showed the drug "has no impact on the coronavirus."

But now that America's Food and Drug Administration has revoked permission for using it to treat coronavirus patients, CNN reports that the U.S. government "is stuck with 63 million doses of hydroxychloroquine." The government started stockpiling donated hydroxychloroquine in late March, after President Trump touted it as "very encouraging" and "very powerful" and a "game-changer." But Monday, the FDA revoked its emergency use authorization to use the drug to treat Covid-19, saying there was "no reason to believe" the drug was effective against the virus, and that it increased the risk of side effects, including heart problems... [M]any infectious disease experts, including those who've studied the drug for coronavirus, say there was never any evidence that the drug worked for the virus.
And some of America's states are now also stuck with millions of hydroxychloroquine pills which they're no longer allowed to use to treat COVID-19, reports The Columbus Dispatch: The state of Ohio purchased more than 2 million hydroxychloroquine pills for $602,629 on April 9, Melanie Amato, spokeswoman for the Department of Health, said via email. [And an additional 2 million were donated by an Ohio-based drugmaker...] The FDA change leaves the Ohio Department of Health with more than 4 million pills, which Amato said have a shelf life of about 18 to 24 months... [T]he state can give the drug only to facilities licensed to maintain dangerous prescription drugs...

Utah purchased $800,000 worth of the drug and Oklahoma spent $2 million on it...

A spokeswoman for Ohio House Speaker Larry Householder, a Glenford Republican, called the state Health Department's purchase of hydroxychloroquine "a waste of money."

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