cortex writes "I routinely need to analyze large datasets (principally using Matlab). I recently 'upgraded' to 64-bit Vista so that I can access larger amounts of RAM. I know that various Linux distros have had 64-bit support for years. I also typically use Intel motherboards for their reliability, but currently Intel's desktop motherboards only support 8GB of RAM and their server motherboards are too expensive. Can anyone relate their experiences with working with Vista or Linux machines running with large RAM (>8GB)? What is the best motherboard (Intel or AMD) and OS combination for workstation applications in terms of cost and reliability?"